Anti-ulcer potential of Hedyotis diffusa (Daniri) against Acetylsalicylic acid (Aspirin) induced gastric ulcer in albino mice.

Billones, Kim Irving D. and Sesperes, John Kenneth S. (2010) Anti-ulcer potential of Hedyotis diffusa (Daniri) against Acetylsalicylic acid (Aspirin) induced gastric ulcer in albino mice. Undergraduate thesis, De La Salle University - Dasmariñas.

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Abstract

The anti-ulcer potential of Hedyotis diffusa, or Daniri, of the family Rubiaceae was evaluated. H. diffusa is a widespread weed found in open lands throughout the Philippines and all over subtropical areas. Studies on the chemical properties of the plant revealed that it contained anthraquinones, flavonoids and ursolic acid [Zhou et al. 2007]. A total of 36 albino mice were used and were divided into three groups of 12 animals each. T0 was given normal saline solution at 0.003 ml/g dosage and T1 was given the same dosage of normal saline solution every 12 hours and aspirin at a dosage of 0.19 mg/g/day. T2 was treated similarly, except that the normal saline solution was replaced with H. diffusa extract at a dose of 0.15 ml/g/day. T1, which received aspirin at a dose of 0.19 mg/g, demonstrated a fifty percent survival rate, while T2, which received the same dose of aspirin and the H.diffusa extract, demonstrated a hundred percent survival. This suggests that the extract may have protected the mice from the adverse effect of the high dose of aspirin. For the histopathological examinations, T0 was found to be ulcer free. T1 was found to have a single occurrence of ulcer. The ulcer detected did not reach the submucosa of the stomach. All the other test subjects from T1 were observed to have hyperplasia and dysplasia. Test subjects from T2 did not develop ulcers, however, all the test subjects were observed to have hyperplasia and dysplasia. The H. diffusa extract does not present any significant effect on the occurrence of gastric ulcer

Item Type: Thesis (Undergraduate)
Additional Information: CALL NUMBER : BIO 1106 2010
Keywords: Anti-ulcer potential.
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QL Zoology
R Medicine > RM Therapeutics. Pharmacology
Users: College of Science and Computer Studies > Biological Science
Depositing User: Ivyjoy Viray
Date Deposited: 01 Dec 2015 01:26
Last Modified: 01 Dec 2015 01:26
URI: http://thesis.dlsud.edu.ph/id/eprint/929

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