Effects of Caesalpinia pulcherrima (L.) Sw. (caballero) on carbontetrachloride-induced liver injury in albino rats.

Reyes, Alexander Cezar C. and Lagdameo, Nonette Merjorie D. (2013) Effects of Caesalpinia pulcherrima (L.) Sw. (caballero) on carbontetrachloride-induced liver injury in albino rats. Undergraduate thesis, De La Salle University - Dasmariñas.

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Abstract

The present study was carried out to evaluate the hepatoprotective effect of the methanol extract of Caesalpinia pulcherrima (MECP) (Family: Caesalpiniaceae) in male albino rats. The different groups of animals were administered with carbon tetrachloride (CCl4) (30 % CCl4, 1 ml/kg b. wt. in liquid paraffin (i.p.) at 72 h interval). The MECP at the doses of 50, 100 and 200 mg/kg were administered to the CCl4 treated rats. The effect of MECP on the level of serum glutamyl pyruvate transaminase (SGPT), Serum glutamyl oxalacetic acid transaminases (SGOT) were measured in the CCl4 induced hepatotoxicity in rats. Furthermore, the liver was taken out and was used for histopathological analysis. The MECP produced a significant (p < 0.05) hepatoprotective effect by decreasing the levels of the enzymes in blood in a dose dependent manner. MECP in dose of 200mg/kg b.w showed a promising potent hepatoprotective property. The histopathological analysis also showed that the liver from the group that received the highest dose of MECP have no significant difference from the normal liver tissue. From these results, it was suggested that MECP possess potent hepatoprotective and antioxidant properties.

Item Type: Thesis (Undergraduate)
Additional Information: CALL NUMBER : BIO 1247 2013
Keywords: 1. Injury
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QK Botany
Users: College of Science and Computer Studies > Biological Science
Depositing User: Ivyjoy Viray
Date Deposited: 19 Nov 2015 00:57
Last Modified: 29 May 2020 07:05
URI: http://thesis.dlsud.edu.ph/id/eprint/758

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