Nobles, Stephanie O. and Ponteras, Cheyenemaika T. (2013) Antiogenic potential of selected Philippine weeds to the chorioallantoicmembrane (CAM) of 10-day old chick embryo. Undergraduate thesis, De La Salle University-Dasmariñas.

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Abstract

Weeds are plants that have no economic use and are considered as agricultural pests. In other countries weeds are used to make herbal decoctions but are not used in for any medical application in the Philippines. Literature reports on the biochemical evidence of the following weeds to contain tannins and flavonoids which possess anti-cancer and anti-oxidant properties: Saccharum spontaneum (talahib), Imperata cylindrica (cogon grass) and Oxalis corniculata (taengang daga). However, angiogenic potential of these plant extracts has not been elucidated. In this study, these three plant samples were used to test their angiogenic potential on the chorioallantic membrane (CAM) of a 10-day-old chick embryo (Gallus gallus). 300 grams of the samples, talahib, cogon grass and taengang daga were immersed in 80% ethanol, while the extracts were collected using the rotary evaporator. Increasing concentrations of each extracts were made (100ppm, 200ppm and 300ppm) and administered onto the CAM of 120 fertilized chicken eggs. After 48 hours, the CAM of each test egg was harvested and collaterals were then counted and compared. Results showed that the three plant extracts were able to inhibit the formation of new blood vessels due to the reduction of the collaterals in all the treated groups when compared to the control. Furthermore, statistical analysis demonstrated that all treatments/concentrations are favorable angiogenic inhibitor (p<0.05). Among the treated groups, cogon grass extract at 200ppm concentration had inhibited the growth of blood vessels the most. It was also observed that at 300 ppm, all plant extracts inhibited angiogenesis to the same extent. Although samples should be increased, this study still presents preliminary data on the angiogenic potential of weeds and its importance as a possible source of drugs for the treatment of cancer and other diseases.

Item Type:	Thesis (Undergraduate)
Additional Information:	BIO 1218 2013
Keywords:	Antiogenic potential ; Weeds
Subjects:	Q Science > QH Natural history > QH301 Biology Q Science > QK Botany Q Science > QL Zoology
Users:	College of Science and Computer Studies > Biological Science
Depositing User:	Ivyjoy Viray
Date Deposited:	11 Nov 2015 05:39
Last Modified:	28 Jun 2021 07:54
URI:	https://thesis.dlsud.edu.ph/id/eprint/429

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